Morin hydrate
Morin hydrate
CAS: 480-16-0
Molecular Formula: C15H10O7
Morin hydrate - Names and Identifiers
| Name | Morin hydrate |
| Synonyms | MORIN Morin Fustic FUSTIC CI 75660 C.I. 75660 CI NO 75660 Morin hydrate Morin dihydrate Morin (C.I. 75660) TIMTEC-BB SBB008853 C.I. Natural Yellow 8 2,3,4,5,7-Pentahydroxyflavone 3,5,7,2',4'-PENTAHYDROXYFLAVONE 2',3,4',5,7-PENTAHYDROXYFLAVONE 2-(3,5-dihydroxyphenyl)-3,6,8-trihydroxy-4H-chromen-4-one 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on |
| CAS | 480-16-0 |
| EINECS | 207-542-9 |
| InChI | InChI=1/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H |
| InChIKey | YXOLAZRVSSWPPT-UHFFFAOYSA-N |
Morin hydrate - Physico-chemical Properties
| Molecular Formula | C15H10O7 |
| Molar Mass | 302.24 |
| Density | 1.3616 (rough estimate) |
| Melting Point | 299-300°C (dec.)(lit.) |
| Boling Point | 363.28°C (rough estimate) |
| Flash Point | 249.3°C |
| Water Solubility | 0.25g/L(20 ºC) |
| Solubility | Soluble in ethanol, hardly soluble in water, slightly soluble in ether and acetic acid. |
| Vapor Presure | 2.94E-17mmHg at 25°C |
| Appearance | gray-yellow needle crystal |
| Color | yellow |
| Merck | 6269 |
| pKa | 6.30±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.4790 (estimate) |
| MDL | MFCD00006826 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Mulberry, ginseng. |
Morin hydrate - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS | LK8749000 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29329990 |
| Toxicity | LD50 intraperitoneal in mouse: 555mg/kg |
Morin hydrate - Reference
| Reference Show more | 1. Sun, Lian, Meng, Lei, et al. Simultaneous determination of six components in Xinjiang Ramulus Mori by HPLC [J]. Chinese Journal of Modern Applied Pharmacy 2013 030(006):660-663. 2. Bai Shuwei, Li Fengzhi, Yao Qian. Effect of Morin on the growth and apoptosis of retinoblastoma [J]. Ophthalmology, 2016(3):171-174. 3. Lyu, Yunbin, et al. "Identification and characterization of three flavonoid 3-o-glycosyltransfers from Epimedium koreanum Nakai." Biochemical Engineering Journal 163 (2020): 107759.https://doi.org/10.1016/j.bej.2020.107759 4. [IF = 2.896] Lu Wang et al."Rapid assay for testing superoxide anion radical scavenging activities to natural pigments by ultra-high performance liquid chromatography-diode-array detection method."Anal Methods-Uk. 2015 Feb;7(4):1535-1542 5. [IF=9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: Potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids."Chem Mater. 2021;33(20):8036-8051 6. [IF=7.514] Yuan Cheng et al."Dual effects of quercetin on protein digestion and absorption in the digestive tract."Food Chem. 2021 Oct;358:129891 7. [IF=6.023] Yajing Fang et al."Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells."Fo 8. [IF=5.833] Zhou Zhidu et al."Ultra-sensitive amperometric determination of quercetin by using a glassy carbon electrode modified with a nanocomposite prepared from aminated graphene quantum dots, thiolated β-cyclodextrin and gold nanoparticles."Microchim Acta. 2020 9. [IF=4.932] Qingyu Meng et al."Morin hydrate inhibits atherosclerosis and LPS-induced endothelial cells inflammatory responses by modulating the NFκB signaling-mediated autophagy."Int Immunopharmacol. 2021 Nov;100:108096 10. [IF=3.978] Yunbin Lyu et al."Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai."Biochem Eng J. 2020 Nov;163:107759 11. [IF=3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China."J Pharmaceut Biomed. 2019 Aug;172:268 12. [IF=5.279] Yajing Fang et al."Transport and Interactions of Co-incubated Bi-functional Flavonoids through Inhibiting the Function of P-Glycoprotein (P-gp) Using KB/Multidrug-Resistant (MDR) Cells and Rat Everted Gut Sacs."J Agr Food Chem. 2022;70(6):1923-1933 13. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 14. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 15. [IF=2.863] Jue Cui et al."Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells."Food Science & Nutrition |
Morin hydrate - Nature
Open Data Verified Data
Morin is a flavonoid derivative, which is a pale yellow or yellow needle-like crystal or amorphous powder. Molecular weight 302. 24, melting point 299~300 ℃ (decomposition). There are three forms of one water, three water and water. Slightly soluble in hot water and alkaline aqueous solution, soluble in ethanol, alkaline conditions were yellow or orange, iron ion discoloration. Natural products are mainly found in the roots and bark of South American yellow wood and Chinese mulberry.
Last Update：2024-01-02 23:10:35
Morin hydrate - Preparation Method
Open Data Verified Data
The Root or wood part of the yellow wood tree was extracted by ethanol immersion and refined.
Last Update：2022-01-01 11:15:28
Morin hydrate - Application
Open Data Verified Data
can be used as a food antioxidant.
Last Update：2025-08-19 16:24:40
Morin hydrate - Reference Information
| color index | 75660 |
| LogP | 1.27-1.54 at 37℃ and pH7.4 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | phignin belongs to polyphenol compounds, which can be used as natural pigments, and have good antioxidation, scavenging free radicals, anti-tumor and hypoglycemic medicinal effects, and have high utilization value. |
| Background | Phellinus chinensis, also known as Sanger, Hu Sun Eye, and Plum Tree Fungus, is a rare perennial large-scale edible and medicinal fungus, belonging to Basidiomycetes (Basidiomycota), Layer Fungus (Hymenomycetes), Polyporus (Polyporales), Polyporus (Polyporaceae), Needle Layer Fungus (Phelliunus), it is mainly parasitic on the trunks of broad-leaved trees such as mulberry, birch, and poplar, and has the reputation of "forest gold. According to the current research shows that there are no less than 100 kinds of chemical substances in Phellinus chinensis, and most of these chemical substances have pharmacological activity, can treat a variety of diseases, and have good application and development prospects. |
| preparation | a method for static adsorption of phignin from phellinus by macroporous resin includes the following steps:(1) preparation of seed liquid: take a well-grown phellinus plate, use a sterilized hole punch, and take 5 pieces of bacteria cake with a diameter of 0.5cm and consistent growth, it was added into a 250mL triangular flask containing 100mL of liquid culture medium, kept at a constant temperature of 28 ℃, rotated at 180r /min, cultured for 7 days, and then smashed mycelial balls with a high-speed homogenizer to prepare seed liquid. Among them, Phellinus igniarius was purchased from the strain preservation center of China Academy of Agricultural Sciences, numbered ATCC36121. The liquid culture medium consists of the following components: 20g of glucose, 0.46g of potassium dihydrogen phosphate, 1g of dipotassium hydrogen phosphate, 0.5g of magnesium sulfate heptahydrate, 2g of peptone, 2g of yeast powder and 1L of deionized water;(2) Fermentation culture: inoculate the seed liquid with an inoculation amount of 10% by volume into a fermentation tank with a liquid volume of 4.5L, and then culture at 28 ℃,180r /min and a ventilation volume of 0.6vvm for 8 days, to obtain fermentation broth;(3) Filtration: The fermentation broth is filtered through filter paper to remove mycelial balls to obtain fermentation filtrate. The concentration of phellin in the fermentation filtrate is 6.78 mg/mL;(4) Adsorption: Adjust the pH value of the fermentation filtrate to 5, then add macroporous resin, shake for 24 hours at 20 ℃ and 150r /min, and reach adsorption equilibrium at this time; Among them, the ratio relationship between fermentation filtrate and macroporous resin is 1mL:4g; The macroporous resin is ADS-17;(5) Analysis: filter the macroporous resin with equilibrium adsorption, wash the sample solution on the surface, put it into a container, add an ethanol solution with a volume percentage of 70%, shake for 24 hours at 20 ℃ and a rotating speed of 150r /min, then reach the complete analysis, and then concentrate the analyzed liquid, purified to prepare phignin. |
| uses | morin has anti-cancer, anti-inflammatory, immunomodulatory and antioxidant effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It can inhibit enzyme activity, has antioxidant, anti-pain, antibacterial, anti-inflammatory, anti-atherosclerosis, lower blood sugar and anti-stress effects. |
| production method | the root or wood part of yellow wood tree is soaked and extracted with ethanol, and then refined. |
Last Update：2024-04-09 21:21:28
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View History
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